Modeling the Unfolded Protein
Response in the Endoplasmic Reticulum |
Protein-protein interactions underlie the processes of the cell. Certain proteins called chaperones are involved in mediating protein folding, maturation, and transport in the endoplasmic reticulum (ER) of eukaryotic cells. BiP is the resident chaperone of the ER.
It acts as a mediator in returning the cell to homeostasis from adverse
conditions in the cell such as elevated temperatures or lack of nutrients
that can cause damage to proteins. This research takes a computational
approach, describing chaperone interactions in the ER as a set of
reaction-diffusion equations.
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